Do not take Promethazine Hydrochloride 25mg Tablets if:
- The person taking the medicine (as tablets) is under 6 years of age.
- You are allergic (hypersensitive) to Promethazine Hydrochloride or any of the other ingredients of Promethazine Hydrochloride 25mg Tablets. Signs of an allergic reaction include: a rash, swallowing or breathing problems, swelling of your lips, face, throat or tongue.
- You are taking a medicine for depression called a monoamine oxidase inhibitor (MAOI). Also do not take Promethazine Hydrochloride 25mg Tablets if you have stopped taking one of these MAOI medicines within the last 14 days. If you are not sure ask your doctor or pharmacist.
- The person is unconscious (in a coma) or suffers from severe dizziness, drowsiness or headache.
If you are not sure if any of the above apply to you, talk to your doctor or pharmacist before taking Promethazine Hydrochloride 25mg Tablets.
Warnings and precautions
Check with your doctor or pharmacist before taking this medicine if:
- You have difficulty breathing, wheezing, tightness in the chest (asthma) or an infection in your lungs (bronchitis).
- You have seizure disorders such as epilepsy.
- You experience an allergic reaction (see section Side Effects), seek medical help right away.
- You have any serious heart problems.
- You have any personal or family history of heart disease.
- You have irregular heartbeat.
- You develop a fever or an infection. Talk to your doctor immediately as laboratory tests to check your blood count may be required.
- You have liver or kidney problems.
- You have a stomach blockage or difficulty passing water (urine).
- You have hearing problems.
- You have increased pressure in the eye (narrow angle glaucoma).
- You have had something called Reye's Syndrome or possible Reye's Syndrome signs include being sick and confused following a viral illness.
Children and adolescents
Do not use in children less than 6 years of age. Because of the risk of choking, the Promethazine Hydrochloride 25mg Tablets should be avoided in children who have difficulty swallowing tablets.
Exposure to sunlight
Promethazine Hydrochloride 25mg Tablets can make your skin more sensitive to sunlight. Keep out of direct sunlight while taking this medicine.
Tests
Taking Promethazine Hydrochloride 25mg Tablets may affect the results of certain tests. These include some pregnancy tests and skin tests. Promethazine Hydrochloride 25mg Tablets should not be taken at least 3 days before the start of a skin test.
If you are not sure if any of the above apply to you, talk to your doctor or pharmacist before taking Promethazine Hydrochloride 25mg Tablets.
Other medicines and Promethazine Hydrochloride 25mg Tablets
Tell your doctor or pharmacist if you are taking or have recently taken any other medicines. This includes medicines you can buy without prescription, including herbal medicines. This is because Promethazine Hydrochloride 25mg Tablets can affect the way some medicines work. Also some medicines can affect the way Promethazine Hydrochloride 25mg Tablets work.
Do not take this medicine, and tell your doctor, if you are taking or have taken the following in the last 2 weeks:
- Some medicines for depression called monoamine oxidase inhibitors (MAOIs). If you are not sure ask your doctor or pharmacist.
Also tell your doctor or pharmacist if you are taking, have recently taken or might take any of the following:
- Anticholinergic medicines - includes some medicines used for irritable bowel syndrome, asthma or weak bladder. These can increase the risk of dizziness, dry mouth and blurred eyesight.
- Medicines for mental health problems (antipsychotics such as haloperidol and quetiapine) or depression (antidepressants such as amitriptyline and citalopram).
- Medicines to help you to sleep or feel more relaxed (such as diazepam or zolpidem).
- Medicines such as aspirin (for arthritis and pain in your joints). Promethazine Hydrochloride 25mg Tablets may hide the side effects of these medicines.
- Medicines for the treatment of irregular heartbeats (antiarrhythmics such as quinidine and amiodarone).
- Medicines that can affect your heart rhythm.
- Medicines for the treatment of epilepsy or seizures.
- Antimicrobials (such as erythromycin and levofloxacin) for the treatment of infections.
Promethazine Hydrochloride 25mg Tablets with alcohol
Do not drink alcohol while you are taking Promethazine Hydrochloride 25mg Tablets. This is because it can affect the way the medicine works.
Pregnancy and breast-feeding
Use of Promethazine Hydrochloride 25mg Tablets is not recommended during pregnancy. Talk to your doctor or pharmacist before taking this medicine if you are a woman of childbearing age and not using effective contraception, or if you are pregnant, think you may be pregnant, or might become pregnant. Promethazine Hydrochloride 25mg Tablets should not be taken 2 weeks before child birth.
Do not take Promethazine Hydrochloride 25mg Tablets if you are breast-feeding. This is because small amounts may pass into mothers' milk. This can be harmful to your baby.
If you are breast-feeding or planning to breast-feed, talk to your doctor or pharmacist before taking any medicine.
Driving and using machines
You may feel drowsy or sleepy after taking this medicine or the morning after taking this medicine. If this happens, do not drive or use any tools or machines. You should not drive a vehicle or operate machinery until you know how Promethazine Hydrochloride 25mg Tablets affect you.
Promethazine Hydrochloride 25mg Tablets contains lactose:
This is a type of sugar. If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.
Possible side effects
Like all medicines, Promethazine Hydrochloride 25mg Tablets can cause side effects, although not everybody gets them. If you notice any of the following serious side effects, stop taking Promethazine Hydrochloride 25mg Tablets and seek immediate medical attention:
- An allergic reaction: Signs may include a rash, itching, difficulty breathing, shortness of breath, swelling of your lips, face, throat or tongue, cold, clammy skin, palpitations, dizziness, weakness or fainting.
- Liver problems: May cause the eyes or skin to go yellow (jaundice) and darkening of urine.
- Muscle stiffness or shaking, unusual movements of the tongue, facial muscle spasms or being unable to control some muscles in your face, rolling eyes and trembling.
- Very fast, irregular, uneven or forceful heartbeat (palpitations).
- General weakness, more frequent infections (particularly throat infection) and fever due to changes in the blood (agranulocytosis, eosinophilia, thrombocytopenia).
- Tiredness which lasts for a long time, possibly due to anaemia.
- A feeling of aggression, hallucinations, and over-active behavior in children.
Tell your doctor or pharmacist if any of the following side effects get serious or lasts longer than a few days, or if you notice any side effects not listed in this leaflet:
- Dry mouth, blurred vision or you cannot pass water (urine).
- Feeling drowsy or sleepy, tiredness, disorientation, having nightmares, headaches, feeling restless.
- Loss of appetite (anorexia), indigestion or irritated stomach.
- Feeling dizzy, lightheaded, faint (hypotension).
- Feeling confused, especially in elderly people.
- Being more sensitive to the sun than usual. If this happens, keep out of direct sunlight and do not use sun lamps.
- Unpleasant sensation or an overwhelming urge to move the legs (also called Restless Legs Syndrome).