Osteopen 100mg/ml Injection for Dogs 10ml

Effective Relief for Canine Joint Issues

Osteopen 100mg/ml Injection for Dogs 10ml contains Pentosan Polysulphate Sodium, an active substance known for its beneficial effects on joint health. It works by supporting the cartilage, improving joint fluid quality, and reducing inflammation, helping to alleviate pain and improve mobility in dogs suffering from osteoarthritis.

 At Weldricks Pharmacy, we understand the importance of providing reliable and accessible veterinary medicines to help your beloved pets.

Why Choose Weldricks for Your Pet's Prescription?

• Trusted UK Pharmacy: We are a family-run pharmacy with nearly 100 years of experience, committed to professional and accessible healthcare.
• Convenient Service: Easily order your vet-prescribed Osteopen 100mg/ml Injection for Dogs 10ml online after your vet has provided a valid prescription.
• Fast & Discreet Delivery: Enjoy free UK delivery on orders over £40, with options for next day delivery and plain, discreet packaging.
• Highly Rated: Join over 85,000 satisfied customers who rate us 4.9/5 on Trustpilot and Reviews.io.

Always follow your veterinary surgeon's advice regarding the diagnosis and treatment plan for your dog, our team is here to support you with reliable dispensing.

Dosage for each species, routes and method of administration

• Route of Administration: Subcutaneous use.
• Dosage: 3 mg pentosan polysulphate sodium / kg bodyweight (equivalent to 0.3 ml/10kg bodyweight) on four occasions, with an interval of 5-7 days.

Advice on correct administration

• Administer by aseptic subcutaneous injection only.
• An appropriately graduated syringe must be used to allow accurate administration of the required dose volume. This is particularly important when injecting small volumes.
• To establish the appropriate dosage, the weight of the individual animal should be determined prior to administering the veterinary medicinal product.

Shelf-life and Storage after Opening

• Shelf-life after first opening the immediate packaging: 84 days.

Contraindications

Do not use Osteopen 100mg/ml Injection for Dogs 10ml:

• In the treatment of septic arthritis; appropriate antimicrobial therapy should be instigated in such cases.
• In dogs with advanced liver or kidney impairment, or evidence of infection.
• In cases of hypersensitivity to the active substance or to any of the excipients.
• In the skeletally immature dog (i.e., dogs whose long bone growth plates have not closed).
• In dogs with blood disorders, coagulation disorders, bleeding, trauma or malignancy (especially haemangiosarcoma).
• During the peri-operative period within 6-8 hours of surgery, as pentosan polysulphate has an anticoagulant effect.
• In arthritides of immunological origin (e.g., rheumatoid arthritis).

Special warnings for the target species

• Do not exceed the standard dose. Increasing the recommended dose may result in exacerbation of stiffness and discomfort.
• Because of the fibrinolytic action of pentosan polysulphate sodium, the possibility of internal bleeding from a tumour or vascular abnormality should be considered and appropriate therapeutic action taken.
• Use with caution in dogs with a history of pulmonary lacerations.
• Caution is also recommended in cases of hepatic impairment.
• Pentosan polysulphate sodium has an anticoagulant effect. It is recommended that the Packed Cell Volume (PVC) and capillary filling time should be monitored.
• Avoid intramuscular injection because of the risk of haematoma at the injection site.
• No more than three courses of four injections should be administered in a twelve-month period.
• Monitor the animal for signs of blood loss and treat appropriately. Interrupt treatment if signs of increased bleeding occur.
• A clinical effect may not be observed until after the second injection of the course of treatment.

Special precautions to be taken by the person administering the veterinary medicinal product to animals

• The preservative, benzyl alcohol, can cause hypersensitivity (allergic) reactions in sensitised people. If you are sensitised, care should be taken when handling this veterinary medicinal product.
• If accidental skin or eye contact occurs, rinse affected area immediately with water.
• Wash hands after use.

Pregnancy and lactation

• Safety has not been studied in pregnant or lactating animals; therefore, use is not recommended.
• Do not use at the time of parturition due to its anticoagulant effects.

Interaction with other medicinal products and other forms of interaction

• NSAIDs, particularly aspirin, should not be used in combination with pentosan polysulphate sodium as they may affect thrombocyte adhesion and potentiate the anticoagulant activity.
• Corticosteroids have been shown to be antagonistic to a number of actions of pentosan polysulphate sodium.
• Do not use concurrently with steroids or non-steroidal anti-inflammatory drugs (including aspirin and phenylbutazone) or within 24 hours of such administration.
• Do not use in conjunction with heparin and other anti-clotting agents.

Overdose

• At three times the recommended dose, a transient increase in bleeding time (approx. 3-4 hours) has been observed.
• Repeated daily overdoses of five times or more the recommended dose resulted in anorexia and depression (reversible upon withdrawal).
• Overdose may cause hepatocellular damage and dose-dependent elevation in ALT.
• Increases in aPTT and TT are dose-dependent and may persist beyond 1 week after administration at doses greater than five times recommended. Signs include bleeding into the gastro-intestinal tract, body cavities, and ecchymoses.
• Overdoses greater than ten times recommended may result in fatality due to gastro-intestinal haemorrhage.
• If overdose occurs, dogs should be hospitalised, observed, and supportive therapy provided as deemed necessary by the veterinarian.

Major incompatibilities

• In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products.

 Adverse events (Dogs)

• Rare (1 to 10 animals / 10,000 treated): Injection site reaction.
• Very rare (1 animal / 10,000 treated): Vomiting, depression and lethargy, prolonged activated partial thrombin time (APTT) and thrombin time (TT).
• Undetermined frequency (cannot be estimated from available data): Emesis, diarrhoea, anorexia, bleeding disorders (e.g., nasal bleeding, haemorrhagic diarrhoea, haematomas), local reactions (e.g., swelling).

Special precautions for disposal

• Medicines should not be disposed of via wastewater or household waste.
• Use take-back schemes or consult your veterinary surgeon or pharmacist for proper disposal of unused veterinary medicinal product or waste materials.

Composition

Each ml of Osteopen 100mg/ml Solution for injection contains:

• Active substance: Pentosan Polysulphate Sodium 100 mg
• Excipient: Benzyl Alcohol E1519 10.45 mg

The solution is a clear, pale yellow aqueous solution.